Then said his wife unto him, Dost thou still retain thine integrity? Job's wife had said nothing when the other calamities had taken place—then she had "refrained her tongue, and kept silence," though probably with some difficulty.
Now she can endure no longer. To see her husband so afflicted, and so patient under his afflictions, is more than she can bear. Her mind is weak and ill regulated, and she suffers herself to become Satan's ally and her husband's worst enemy.
It is noticeable that she urges her husband to do exactly that which Satan had suggested that he would do (Job 1:11; Job 2:5), and had evidently wished him to do, thus fighting on his side, and increasing her husband's difficulties The only other mention of her (Job 19:17) implies that she was rather a hindrance than a help to Job.
Curse God, and die; i.e. "renounce God, put all regard for him away from thee, even though he kill thee for so doing." Job's wife implies that death is preferable to such a life as Job now leads and must expect to lead henceforward.