Have estranged this place; rather, have treated this place as strange; i.e. as one that did not belong to their God, that was unholy (comp. Jeremiah 16:18, "They have defiled ray land"). With the blood of innocents; comp."
Innocent blood, even the blood of their sons and of their daughters" (Psalms 106:38)—the children sacrificed in Hinnom to Moloch.